On Earth-2, Detective Jim Corrigan operated from Gateway City as the host of The Spectre in the 1940s. As Corrigan handled various magic and spirit-based cases within the city, while also periodically aiding the Justice Society of America, the reality of Earth-2 was eventually over-written following the Crisis on Infinite Earths and replaced by the New Earth reality.
In this new reality, Jim Corrigan was said to have operated out of New York City and had never set foot in Gateway City.
Some time after the Crisis on Infinite Earths, in the New Earth reality, following Artemis' death while she was serving as the new Wonder Woman, Princess Diana of Themyscira, following the advice of Julia Kapatelis, re-assumed the mantle of Wonder Woman and attempted to start annew in Gateway City. However, Darkseid, attempting to learn the location of the Greek Gods by capturing and interrogating her, had anticipated her arrival and had begun supplying the local criminals with advanced weaponry in order to lure her into a trap.
After returning from Apokolips and Themyscira, Diana took a job as a visiting lecturer on Greco-Roman mythology at the Gateway City Museum of Cultural Antiquities and became fast friends with the museum's director Helena Sandsmark and her daughter, Cassandra Sandsmark.
Following Morgane Le Fay's attempt at re-obtaining her immortality by stealing it from other immortals, Jason Blood relocated to live in Gateway and began a relationship with Helena Sandsmark, although she did not know about his immortality and contract with Etrigan the Demon.
After quelling a rampant artificial intelligence that was creating artificial clones of various super power beings such as Flash (Barry Allen), Sinestro and Doomsday, Diana encounters a new superhero named Champion and inadvertently inspired Cassandra Sandsmark to take up heroics through using various artifacts to gain superpowers.
After Cheetah sold her soul to Neron to resurrect Chuma, Chuma took her to Gateway in an attempt to get Diana to help her regain control over her primal urges and regain her soul. Shortly thereafter, Artemis, having returned from hell and now operating as a demon hunter, arrived at Gateway in pursuit of Jason Blood.
As Diana died while fighting Neron and became the Goddess of Truth, Hippolyta took up the role of Wonder Woman, temporarily operating in Gateway before time traveling to the 1940's with Jay Garrick and fighting in World War II. Diana soon returned to Earth and became targeted by the Titan of Myth, Titan, who enacted a violent gang war within the city in preparation for Cronus' war against the Olympian Gods. This attack occurred as Diana began having doubts over whether she was having any affect in the world, in contrast to Artemis' more violent methods that she exhibits while on her vigilante patrols within the city.
As the invisible jet came under the influence of the Titan of Myth, Oblivion, a portion of Gateway was destroyed; including the Sandsmark's home.
Saved with the assistance of Batman and Superman, Diana decided to leave Gateway City and operate from the newly formed Wonderdome while Artemis stayed with Cassandra to train her as an Amazon until, following an attack by the Titan's own champion, Devastation, Cassandra was deemed competent to hold her own and Artemis returned to Themyscira while Diana left the Wonderdome to live with Donna Troy in New York.
Meanwhile, businessman Sebastian Ballesteros had allied with Circe and captured Vanessa Kapatelis to turn her into a new Silver Swan, using his dockyard shipping headquarters at the Gateway Wharf to control her into attacking Diana through first destroying the Sandsmark's residence, attacking the Gateway City Museum of Cultural Antiquities, and then attacking Dennis Peterson High School; publicly outing Cassandra Sandsmark as Wonder Girl.